One out of three people may have reduced ability to produce enough methyl enzyme. It’s a very busy enzyme. Lower producers will be impacted in many ways including inability to get B12 and Folic Acid in to the cells where it is needed. These Bs are essentials for nerve health. Children struggling with weakness, fatigue, difficulty holding head up or sitting upright, torticollis, or dystonia might be low on folic acid at the cellular level. See below for a list of the uses of folic acid in the body.
The solution to not having enough methyl? Take METHYLATED versions of these vitamins so your body can get them to the cellular level. Everyone needs their Bs!!!!
Check your vitamins to find out if the Bs are the activated kind!!!
You want to see METHYLcobalamine and Activated Folinic Acid on the label. Additonal names for the methylated form of folic acid are 5-Methyltetrahydrofolic acid, 5-MTHF, Metafolin or methylfolate.
Here’s an example of a b-complex with activated folinic acid and methylcobalamine available from Whole Foods – about $20/bottle – Amazon $15/bottle
.Link to Amazon site with product description:
The excerpt below is from: http://www.custommedicine.com.au/health-articles/folinic-acid/
A genetic defect called MTHFR gene polymorphism is responsible for dihydrofolate reductase malfunction which prevents the activation of folic acid. A simple blood test (called a MTHFR Gene Test) can determine if you carry this faulty gene and thus are unable to convert folic acid into its active MTHF form. Some researchers believe that up to half of the population may carry this defective gene. Symptoms of this can include weight gain, fatigue and depression. If found to be present it can easily be treated by using folinic acid or better still MTHF.
Folate coenzymes are responsible for the following important metabolic functions:
1) Formation of purines and pyrimidines, which in turn are needed for synthesis of the nucleic acids DNA and RNA. This process allows cell replication to occur and is thus essential. This is especially important during fetal development in the first trimester in preventing birth defects, such as neural tube defects,
2) Formation of heme, the iron-containing protein in hemoglobin. This enables oxygen transport throughout the bodyand thus energy production.
3) Interconversion of the 3-carbon amino acid serine from the 2-carbon amino acid glycine.
4) Formation of the amino acids tyrosine from phenylalanine and glutamic acid from histidine.
5) Methylation of homocysteine into the amino acid methionine. Elevated levels of homocysteine have been implicated in a wide range of health disorders including atherosclerosis, osteoporosis, Alzheimer’s disease, and depression. In the reconversion of homocysteine to methionine the body uses the methionine to make the important amino acid s-adenosylmethionine (SAMe) which is known to be helpful in cases of depression.
6) Synthesis of choline from ethanolamine,
7) Formation and maturation of red and white blood cells, and
8) Conversion of nicotinamide to N’-methylnicotinamide.
9) The production of certain neurotransmitters such as dopamine, adrenaline and noradrenaline rely on the methylation reaction which is dependant on THF.
10) Energy production also relies on the methylation reaction, and thus MTHF, and a slow rate of methylation has been linked to chronic fatigue.